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Article

Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men.

Urologic oncology - 1 Jan 2000

Bangsi Dieudonne, Zhou Junying, Sun Yezhou, Patel Nimesh P, Darga Linda L, Heilbrun Lance K, Powell Isaac J, Severson Richard K, Everson Richard B

Abstract excerpt

Genes involved in androgen metabolism are strong candidates for having an important role in the pathogenesis of prostate cancer. CYP3A4, a protein in the cytochrome P-450 supergene family, facilitates the oxidative deactivation of testosterone. In previous studies, patients with the G variant of...

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Identifiers

PMID: 16414488
DOI: 10.1016/j.urolonc.2005.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16414488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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