Article
Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2000
Lankas G R, Wise L D, Cartwright M E, Pippert T, Umbenhauer D R
Abstract excerpt
A subpopulation of the CF-1 mouse strain contains a spontaneous mutation in the P-glycoprotein (Pgp) mdr1a gene, which leads to a lack of mdr1a expression in the placenta as well as brain and intestine. Individual CF-1 mice can be identified according to their Pgp status by a restriction fragment length polymorphism. Male and female mice selected on the basis of Pgp genotype were mated and the pregnant dams...
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