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Article

The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function.

Developmental biology - 1 Nov 2002

Eimer Stefan, Donhauser Roland, Baumeister Ralf

Abstract excerpt

Mutations in presenilin genes impair Notch signalling and, in humans, have been implicated in the development of familial Alzheimer's disease. We show here that a reduction of the activity of the Caenorhabditis elegans presenilin sel-12 results in a late defect during sex muscle development. The morphological abnormalities and functional deficits in the sex muscles contribute to the egg-laying defects seen in...

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Source

Identifiers

PMID: 12413907
DOI: 10.1006/dbio.2002.0782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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