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Article

A strong nitrogen source-regulated promoter for controlled expression of foreign genes in the yeast Pichia pastoris.

Gene - 17 Aug 1998

Shen S, Sulter G, Jeffries T W, Cregg J M

Abstract excerpt

In methylotrophic yeasts, glutathione-dependent formaldehyde dehydrogenase (FLD) is a key enzyme required for the metabolism of methanol as a carbon source and certain alkylated amines such as methylamine as nitrogen sources. We describe the isolation and characterization of the FLD1 gene from the yeast Pichia pastoris. The gene contains a single short intron with typical yeast-splicing signals near its 5' end,...

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PMID: 9714758
DOI: 10.1016/s0378-1119(98)00315-1

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