Article
Evidence supporting an association between the DRB1 gene and schizophrenia in Japanese.
Schizophrenia research - 27 Jul 1998
Arinami T, Otsuka Y, Hamaguchi H, Itokawa M, Aoki J, Shibuya H, Okubo Y, Iwawaki A, Ota K, Enguchi H, Tagaya H, Yano S, Shimizu H, Toru M
Abstract excerpt
The authors attempted a replication of earlier studies that detected an association of HLA-DR4 and DR1 with schizophrenia. Japanese patients with schizophrenia (n = 266, DSM-III-R criteria) and Japanese controls (n = 283) were genotyped for DR1 and DR4 alleles using a combination of group-specific polymerase chain reaction (PCR) amplification and PCR-restriction fragment length polymorphism. Significant positive...
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