Clonal variability of radiation-induced cisplatin resistant HeLa cells.

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Article

Clonal variability of radiation-induced cisplatin resistant HeLa cells.

Anticancer research - 1 Jan 2000

Eichholtz-Wirth H, Marx K

Abstract excerpt

Low-dose fractionated gamma-irradiation (3 cycles of 5x2 Gy) induces moderate cisplatin resistance in HeLa cells which is associated with alterations of the caspase-dependent apoptotic pathway (2). There is a considerable heterogeneity in cell survival among isolated resistant clones (Rf values b...

Topics

Antineoplastic Agents
Apoptosis
Cell Survival
Cisplatin
Clone Cells
Drug Resistance, Neoplasm
Gamma Rays
Genetic Variation
HeLa Cells
Humans
NF-kappa B
Proto-Oncogene Proteins
Radiation-Sensitizing Agents
Transcription Factor RelB
Transcription Factors
Tumor Necrosis Factor-alpha
fas Receptor

Source

Open in PubMed

Identifiers

PMID: 9713497

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9713497-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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