Article
Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy.
The Journal of clinical endocrinology and metabolism - 1 Aug 1998
Shah V O, Scavini M, Nikolic J, Sun Y, Vai S, Griffith J K, Dorin R I, Stidley C, Yacoub M, Vander Jagt D L, Eaton R P, Zager P G
Abstract excerpt
Epidemiological studies support the hypothesis that genetic factors modulate the risk for diabetic nephropathy (DN). Aldose reductase (ALDR1), the rate-limiting enzyme in the polyol pathway, is a potential candidate gene. The present study explores the hypothesis that polymorphisms of the (A-C)n dinucleotide repeat sequence, located 2.1 kb upstream of the transcription start site, modulate ALDR1 gene expression...
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