Article
Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy.
The Journal of clinical endocrinology and metabolism - 1 Aug 1998
Shah V O, Scavini M, Nikolic J, Sun Y, Vai S, Griffith J K, Dorin R I, Stidley C, Yacoub M, Vander Jagt D L, Eaton R P, Zager P G
Abstract excerpt
Epidemiological studies support the hypothesis that genetic factors modulate the risk for diabetic nephropathy (DN). Aldose reductase (ALDR1), the rate-limiting enzyme in the polyol pathway, is a potential candidate gene. The present study explores the hypothesis that polymorphisms of the (A-C)n...
Topics
- Adult
- Aldehyde Reductase
- Alleles
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Female
- Gene Expression
- Genotype
- Homozygote
- Humans
- Male
- Microsatellite Repeats
- Middle Aged
- Risk Factors