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Article

Aldose reductase expression is induced by hyperglycemia in diabetic nephropathy.

Kidney international - 1 Jul 2001

Hodgkinson A D, Søndergaard K L, Yang B, Cross D F, Millward B A, Demaine A G

Abstract excerpt

BACKGROUND: Despite good metabolic control, many patients with type 1 diabetes still develop nephropathy, implicating a role for genetic factors. Recent studies examining the regulatory region of the aldose reductase (ALR2) gene, the rate-limiting enzyme of the polyol pathway, support its role as a candidate gene for nephropathy. Here we report the quantitation of ALR2, together with sorbitol dehydrogenase mRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11422753
DOI: 10.1046/j.1523-1755.2001.00788.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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