Article
Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population.
Neuroscience letters - 12 Jun 2003
Di Natale Manuela, Perri Maria, Kawarai Toshitaka, Maletta Raffaele, Tomaino Carmine, Sato Christine, Nacmias Benedetta, Shibata Nobuto, Sorbi Sandro, St George-Hyslop Peter H, Bruni Amalia C, Rogaeva Ekaterina
Abstract excerpt
Alzheimer disease (AD) is the most common neurodegenerative disorder of aging. Identifying novel AD genetic risk factors is important for understanding its pathogenesis. A recent study demonstrated that the deletion of adenosine in the promoter region of the presenilin 2 gene (PS2) is a susceptibility factor for early-onset AD. The objective of our study was to test the possibility that this variation is...
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