Article
Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.
Annals of neurology - 1 Aug 1996
Xia Y, Rohan de Silva H A, Rosi B L, Yamaoka L H, Rimmler J B, Pericak-Vance M A, Roses A D, Chen X, Masliah E, DeTeresa R, Iwai A, Sundsmo M, Thomas R G, Hofstetter C R, Gregory E, Hansen L A, Katzman R, Thal L J, Saitoh T
Abstract excerpt
The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP...
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