Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice.

Developmental biology - 10 Oct 1996

Swierczynski S L, Siddhanti S R, Tuttle J S, Blackshear P J

Abstract excerpt

The myristoylated alanine-rich C kinase substrate, or MARCKS protein, is a widely expressed, prominent substrate for protein kinase C. Although the exact function of MARCKS has not been elucidated, targeted disruption of the MARCKS gene (Macs) in mice has shown that MARCKS plays a crucial role in the development of the central nervous system. Mice deficient in MARCKS exhibited universal perinatal death with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Line
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mice, Transgenic

Share to Phenotype

Share to Pregnancy

Source

Identifiers

PMID: 8873759
DOI: 10.1006/dbio.1996.0246

Genes

MARCKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice.PMID 8873759Read ↗

Neuroanatomical development in the absence of PKC phosphorylation of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein.Semantic proximity Read ↗

Transgenic complementation of MARCKS deficiency with a nonmyristoylatable, pseudo-phosphorylated form of MARCKS: evidence for simultaneous positive and dominant-negative effects on central nervous system development.Semantic proximity Read ↗

Two myristoylated alanine-rich C-kinase substrate (MARCKS) paralogs are required for normal development in zebrafish.Semantic proximity Read ↗

Myristoylation alters retinoic acid-induced down-regulation of MARCKS in immortalized hippocampal cells.Semantic proximity Read ↗

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.Semantic proximity Read ↗

Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.Semantic proximity Read ↗

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.Semantic proximity Read ↗

Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells.Semantic proximity Read ↗

Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation.Semantic proximity Read ↗

Truncated CASK does not alter skeletal muscle or protein interactors.Semantic proximity Read ↗

Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes.Semantic proximity Read ↗

MARCKS regulates membrane ruffling and cell spreading.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.