Article
Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice.
Developmental biology - 10 Oct 1996
Swierczynski S L, Siddhanti S R, Tuttle J S, Blackshear P J
Abstract excerpt
The myristoylated alanine-rich C kinase substrate, or MARCKS protein, is a widely expressed, prominent substrate for protein kinase C. Although the exact function of MARCKS has not been elucidated, targeted disruption of the MARCKS gene (Macs) in mice has shown that MARCKS plays a crucial role in...
Topics
- Animals
- Brain
- Cell Line
- Female
- Genetic Complementation Test
- Genetic Therapy
- Genetic Vectors
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Membrane Proteins
- Mice
- Mice, Transgenic
- Myristates
- Myristoylated Alanine-Rich C Kinase Substrate
- Phenotype
- Pregnancy
- Protein Kinase C