Article
Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids.
Leukemia - 1 Aug 1998
Jazwiec B, Solanilla A, Grosset C, Mahon F X, Dupouy M, Pigeonnier-Lagarde V, Belloc F, Schweitzer K, Reiffers J, Ripoche J
Abstract excerpt
We investigated the ability of endothelial cells (EC) to support hematopoiesis in contact and non-contact cocultures with isolated CD34+ or CD34/CD38low cells. In the absence of exogenous cytokines, umbilical vein EC (HUVEC) efficiently support proliferation of hematopoietic cells and generation...
Topics
- Antigens, CD34
- Bone Marrow
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Coculture Techniques
- Colony-Forming Units Assay
- Culture Media, Conditioned
- Cytokines
- Down-Regulation
- Endothelium, Vascular
- Fetal Blood
- Glucocorticoids
- Hematopoiesis
- Hematopoietic Stem Cells