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Molecular Profile and Partial Functional Analysis of Novel Endothelial Cell‐Derived Growth Factors that Regulate Hematopoiesis

23 Dec 2005

Abstract excerpt

Recent progress has been made in the identification of the osteoblastic cellular niche for hematopoietic stem cells (HSCs) within the bone marrow (BM). Attempts to identify the soluble factors that regulate HSC self-renewal have been less successful. We have demonstrated that primary human brain endothelial cells (HUBECs) support the ex vivo amplification of primitive human BM and cord blood cells capable of...

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PMID: 16373696
DOI: 10.1634/stemcells.2005-0029

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