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Regulation of Mesenchymal Stem Cell Activity by Endothelial Cells

10 Jun 2010

Abstract excerpt

Emerging data suggest that mesenchymal stem cells (MSCs) are part of a periendothelial niche, suggesting the existence of heterotypic cell-cell crosstalk between endothelial cells and MSCs that regulate MSCs in their local microenvironment. We determined the effects of paracrine factors secreted by human umbilical vein endothelial cells (HUVECs) on MSC survival, proliferation, and differentiation by using an...

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PMID: 20536359
DOI: 10.1089/scd.2010.0168

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