Prion's progress: patterns and rates of molecular evolution in relation to spongiform disease.

doi:10.1007/pl00006370

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Article

Prion's progress: patterns and rates of molecular evolution in relation to spongiform disease.

Journal of molecular evolution - 1 Aug 1998

Krakauer D C, Zanotto P M, Pagel M

Abstract excerpt

Modification of the cellular prion protein has been correlated with the acquisition of several neurodegenerative diseases, including kuru, scrapie, bovine spongiform encephalopathy (BSE), and Creutzfeldt-Jakob disease (CJD). Sequence conservation and amino acid identity are known to influence the...

Topics

Animals
Base Composition
Birds
Cattle
Encephalopathy, Bovine Spongiform
Evolution, Molecular
Genetic Variation
Humans
Mammals
Mutagenesis
Polymorphism, Genetic
Prion Diseases
Prions
Scrapie
Selection, Genetic

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