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Article

Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants.

Biochemistry - 23 Feb 2010

Kirby Louise, Agarwal Sonya, Graham James F, Goldmann Wilfred, Gill Andrew C

Abstract excerpt

Transmissible spongiform encephalopathies (TSEs) are associated with the accumulation of deposits of an abnormal form, PrP(Sc), of the host-encoded prion protein, PrP(C). Amino acid substitutions in PrP(C) have long been known to affect TSE disease outcome. In extreme cases in humans, various mut...

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PMID: 20085368
DOI: 10.1021/bi901855z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20085368-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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