Article
Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia.
Blood - 15 Dec 2000
Nakamura K, Kobayashi M, Konishi N, Kawaguchi H, Miyagawa S, Sato T, Toyoda H, Komada Y, Kojima S, Katoh O, Ueda K
Abstract excerpt
To define the basis for faulty granulopoiesis in patients with severe congenital neutropenia (SCN), the expression of granulocyte colony-stimulating factor receptor (G-CSFR) in primitive myeloid progenitor cells and their responsiveness to hematopoietic factors were studied. Flow cytometric analysis of bone marrow cells based on the expression of CD34, Kit receptor, and G-CSFR demonstrated a reduced frequency of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.