Article
Relation between microsatellite instability and N-ras mutation and duration of disease free survival in patients with acute leukemia.
Cancer - 1 Aug 1998
Tanosaki S, Inokuchi K, Shimada T, Dan K
Abstract excerpt
BACKGROUND: Microsatellite instability (MIN) appears to be a novel molecular mechanism in carcinogenesis and is believed to reflect multiple replication errors. The authors analyzed MIN in de novo acute leukemia and its association with expression of the human MSH3 (hMSH3) gene and point mutation...
Topics
- Acute Disease
- Adolescent
- Adult
- Aged
- DNA Repair
- DNA-Binding Proteins
- Disease-Free Survival
- Female
- Fungal Proteins
- Genes, ras
- Humans
- Leukemia
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation