Autoregulation of the Raf-1 serine/threonine kinase.

doi:10.1073/pnas.95.16.9214

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Article

Autoregulation of the Raf-1 serine/threonine kinase.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998

Cutler R E, Stephens R M, Saracino M R, Morrison D K

Abstract excerpt

The Raf-1 serine/threonine kinase is a key protein involved in the transmission of many growth and developmental signals. In this report, we show that autoinhibition mediated by the noncatalytic, N-terminal regulatory region of Raf-1 is an important mechanism regulating Raf-1 function. The inhibi...

Topics

Animals
Catalysis
Mutation
Proto-Oncogene Proteins c-raf
Xenopus laevis

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