Article
Specific reduction of insulin disulfides by macrophage migration inhibitory factor (MIF) with glutathione and dihydrolipoamide: potential role in cellular redox processes.
FEBS letters - 3 Jul 1998
Kleemann R, Mischke R, Kapurniotu A, Brunner H, Bernhagen J
Abstract excerpt
The molecular mechanism of action of MIF, a cytokine that plays a critical role in the host immune and inflammatory response, has not yet been identified. We recently demonstrated that MIF is an enzyme that exhibits oxidoreductase activity by a cysteine thiol-mediated mechanism. Here we further i...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Line
- Cysteine
- Disulfides
- Glutathione
- Humans
- Hydrogen Peroxide
- Insulin
- Macrophage Migration-Inhibitory Factors
- Macrophages
- Molecular Sequence Data
- Mutation
- Oxidants
- Oxidation-Reduction
- Oxidoreductases
- Reducing Agents