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Article

Topoisomerase mutations in trovafloxacin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Aug 1998

Fitzgibbon J E, John J F, Delucia J L, Dubin D T

Abstract excerpt

A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in DNA topoisomerase genes, including two mutations in the A subunit (encoded by grlA) of...

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Identifiers

PMID: 9687420
DOI: 10.1128/AAC.42.8.2122
PMCID: PMC105881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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