Article
Characterization of the MexC-MexD-OprJ multidrug efflux system in DeltamexA-mexB-oprM mutants of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Aug 1998
Gotoh N, Tsujimoto H, Tsuda M, Okamoto K, Nomura A, Wada T, Nakahashi M, Nishino T
Abstract excerpt
Expression of the multidrug efflux system MexC-MexD-OprJ in nfxB mutants of Pseudomonas aeruginosa contributes to resistance to fluoroquinolones and the "fourth-generation" cephems (cefpirome and cefozopran), but not to most beta-lactams, including the ordinary cephems (ceftazidime and cefoperazo...
Topics
- Animals
- Anti-Infective Agents
- Cephalosporins
- Drug Resistance, Microbial
- Fluoroquinolones
- Mice
- Mice, Inbred BALB C
- Mutation
- Operon
- Pseudomonas aeruginosa
- Rabbits
- Substrate Specificity