Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in pvcABCD operon of Pseudomonas aeruginosa modulates MexEF-OprN efflux system and hence resistance to chloramphenicol and ciprofloxacin.

Microbial pathogenesis - 1 Dec 2020

Iftikhar Anam, Asif Azka, Manzoor Asma, Azeem Muhammad, Sarwar Ghulam, Rashid Naeem, Qaisar Uzma

Abstract excerpt

Pseudomonas aeruginosa harbors pvcABCD operon that is responsible for the synthesis of paerucumarin. Here we report the involvement of pvcABCD operon in chloramphenicol and ciprofloxacin resistance. P. aeruginosa mutant defective in pvcB (PW4832) was more sensitive to chloramphenicol and ciprofloxacin in comparison with its parent strain (MPAO1). A mutation in pvcA gene in MPAO1 (PW4830) did not alter the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Outer Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloramphenicol

Share to Ciprofloxacin

Share to Gene Expression Regulation, Bacterial

Share to Mutation

Share to Operon

Share to Pseudomonas aeruginosa

Source

Identifiers

PMID: 32941967
DOI: 10.1016/j.micpath.2020.104491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in pvcABCD operon of Pseudomonas aeruginosa modulates MexEF-OprN efflux system and hence resistance to chloramphenicol and ciprofloxacin.PMID 32941967Read ↗

MexXY Multidrug Efflux System Is More Frequently Overexpressed in Ciprofloxacin Resistant French Clinical Isolates Compared to Hospital Environment OnesSemantic proximity Read ↗

Genetic Variations in MexAB-OprM Efflux Pump Regulators and Their Association with Antibiotic Resistance and Sequence type in Clinical and Epidemiologically High-risk Clones of Pseudomonas Aeruginosa.Semantic proximity Read ↗

Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosaSemantic proximity Read ↗

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosaSemantic proximity Read ↗

A PhoPQ-Regulated ABC Transporter System Exports Tetracycline in Pseudomonas aeruginosaSemantic proximity Read ↗

MexXY multidrug efflux system of Pseudomonas aeruginosaSemantic proximity Read ↗

MexXY RND pump of Pseudomonas aeruginosa PA7 effluxes bi-anionic β-lactams carbenicillin and sulbenicillin when it partners with the outer membrane factor OprA but not with OprMSemantic proximity Read ↗

Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India.Semantic proximity Read ↗

Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.Semantic proximity Read ↗

Involvement of a novel efflux system in biofilm-specific resistance to antibiotics.Semantic proximity Read ↗

A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa.Semantic proximity Read ↗

Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.