Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.

Journal of chromatography. B, Biomedical sciences and applications - 12 Jun 1998

Henne K R, Gaedigk A, Gupta G, Leeder J S, Rettie A E

Abstract excerpt

A direct chiral-phase high-performance liquid chromatographic method for measuring the ratio of S-warfarin/R-warfarin in patient plasma is described. Plasma samples are first extracted using solid-phase C18 extraction columns, and the concentrated extracts analyzed using an (R,R) Whelk-O 1 column with a mobile phase of 0.5% glacial acetic acid in acetonitrile. The resulting chromatography provides baseline...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Cytochrome P-450 Enzyme System

Share to Evaluation Studies as Topic

Share to Genotype

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 9686881
DOI: 10.1016/s0378-4347(98)00099-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.PMID 9686881Read ↗

Implications of cytochrome P450 2C9 polymorphism on warfarin metabolism and dosing.Semantic proximity Read ↗

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites.Semantic proximity Read ↗

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.Semantic proximity Read ↗

Association Between Genetic Polymorphisms and Steady-State Plasma Concentration of Warfarin Optical IsomersSemantic proximity Read ↗

Quantitative Assessment of CYP2C9 Genetic Polymorphisms Effect on the Oral Clearance of S-Warfarin in Healthy Subjects.Semantic proximity Read ↗

Genetic association between sensitivity to warfarin and expression of CYP2C9*3.Semantic proximity Read ↗

The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers.Semantic proximity Read ↗

Pharmacogenetics of warfarin elimination and its clinical implications.Semantic proximity Read ↗

Simultaneous determination of warfarin and 7-hydroxywarfarin enantiomers by high-performance liquid chromatography with ultraviolet detection.Semantic proximity Read ↗

Warfarin dose adjustments based on CYP2C9 genetic polymorphisms.Semantic proximity Read ↗

Phenotyping of CYP2C19 with enantiospecific HPLC-quantification of R- and S-mephenytoin and comparison with the intron4/exon5 G-->A-splice site mutation.Semantic proximity Read ↗

Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.