Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.

doi:10.1016/s0378-4347(98)00099-1

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Article

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.

Journal of chromatography. B, Biomedical sciences and applications - 12 Jun 1998

Henne K R, Gaedigk A, Gupta G, Leeder J S, Rettie A E

Abstract excerpt

A direct chiral-phase high-performance liquid chromatographic method for measuring the ratio of S-warfarin/R-warfarin in patient plasma is described. Plasma samples are first extracted using solid-phase C18 extraction columns, and the concentrated extracts analyzed using an (R,R) Whelk-O 1 column...

Topics

Alleles
Anticoagulants
Aryl Hydrocarbon Hydroxylases
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C9
Cytochrome P-450 Enzyme System
Evaluation Studies as Topic
Genotype
Humans
Reproducibility of Results
Sensitivity and Specificity
Stereoisomerism
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases
Warfarin

Source

Open in PubMed

Identifiers

PMID: 9686881
DOI: 10.1016/s0378-4347(98)00099-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9686881-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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