Article
Simultaneous determination of warfarin and 7-hydroxywarfarin enantiomers by high-performance liquid chromatography with ultraviolet detection.
Therapeutic drug monitoring - 1 Feb 2011
Miura Masatomo, Okuyama Shin, Kato Shoutaro, Kagaya Hideaki, Murata Atsunobu, Komatsuda Atsushi, Wakui Hideki, Sawada Kenichi
Abstract excerpt
Warfarin is administered clinically as a racemic mixture of two enantiomers, (R)-warfarin and (S)-warfarin. (S)-Warfarin has more potent anticoagulant activity than (R)-warfarin and is metabolized mainly to (S)-7-hydroxywarfarin by CYP2C9. A simple, rapid, and sensitive high-performance liquid chromatography method with ultraviolet detection was developed for the simultaneous quantitative determination of the...
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