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Understanding ageing from an evolutionary perspective

21 Jan 2008

Abstract excerpt

There is clear heritability of human longevity. However, the genetics of ageing is likely to be complex. Evolution theory tells us not to expect genes that have been selected to promote ageing. Ageing is not programmed but results from accumulation of somatic damage, owing to limited investments in maintenance and repair. Genes controlling the levels of activities, such as DNA repair and antioxidant defence, thus...

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PMID: 18226090
DOI: 10.1111/j.1365-2796.2007.01901.x

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