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Article

Detection of mutator subpopulations in Salmonella typhimurium LT2 by reversion of his alleles.

Mutation research - 25 May 1998

LeClerc J E, Payne W L, Kupchella E, Cebula T A

Abstract excerpt

Defects in the methyl-directed mismatch repair lead to both the hypermutability phenotype and removal of a barrier to genetic exchange between species. Mutator bacteria carrying such defects occur frequently among bacterial pathogens, suggesting that subpopulations of mutators are contained within pathogen clones and give rise to the genetic variants that are acted upon by selective forces to allow survival or...

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Identifiers

PMID: 9685594
DOI: 10.1016/s0027-5107(98)00069-4

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