Detection of mutator subpopulations in Salmonella typhimurium LT2 by reversion of his alleles.

doi:10.1016/s0027-5107(98)00069-4

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Article

Detection of mutator subpopulations in Salmonella typhimurium LT2 by reversion of his alleles.

Mutation research - 25 May 1998

LeClerc J E, Payne W L, Kupchella E, Cebula T A

Abstract excerpt

Defects in the methyl-directed mismatch repair lead to both the hypermutability phenotype and removal of a barrier to genetic exchange between species. Mutator bacteria carrying such defects occur frequently among bacterial pathogens, suggesting that subpopulations of mutators are contained withi...

Topics

Alleles
DNA Mutational Analysis
Gene Frequency
Histidine
Models, Genetic
Mutagenesis, Site-Directed
Mutation
Phenotype
Salmonella typhimurium

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