Article
Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase.
Virology - 20 Jul 1998
Sahasrabudhe A, Lawrence L, Epa V C, Varghese J N, Colman P M, McKimm-Breschkin J L
Abstract excerpt
We have previously reported the isolation and characterization of an influenza virus variant with decreased sensitivity to the neuraminidase-specific inhibitor zanamivir. This variant, which has a mutation in the active site, Glu 119 Gly (E119G), has the same specific activity as the wild-type ne...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Binding Sites
- Cell Line
- Cell Membrane
- Dogs
- Enzyme Inhibitors
- Enzyme Stability
- Formaldehyde
- Genetic Variation
- Guanidines
- Hymecromone
- In Vitro Techniques
- Kinetics
- Microscopy, Electron
- Neuraminidase
- Orthomyxoviridae