Decreased synthesis of glycosphingolipids in cells lacking vimentin intermediate filaments.

doi:10.1006/excr.1998.4126

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Article

Decreased synthesis of glycosphingolipids in cells lacking vimentin intermediate filaments.

Experimental cell research - 1 Aug 1998

Gillard B K, Clement R, Colucci-Guyon E, Babinet C, Schwarzmann G, Taki T, Kasama T, Marcus D M

Abstract excerpt

We are studying defects in glycosphingolipid synthesis in cells lacking vimentin intermediate filaments (vimentin-). Sugars can be incorporated into glycolipids whose ceramide is synthesized either de novo (pathway 1) or from sphingoid bases salvaged from hydrolysis of sphingolipids (pathway 2) a...

Topics

Animals
Antirheumatic Agents
Carbohydrate Sequence
Chloroquine
Endosomes
Fibroblasts
Glycosphingolipids
Humans
Intermediate Filaments
Lysosomes
Mice
Mutation
Tumor Cells, Cultured
Vimentin

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