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Article

Extensive Cross-Reactivity of Adenovirus-Specific Cytotoxic T Cells

1 Jul 1998

Abstract excerpt

Although adenovirus is a major source of morbidity for immunocompromised individuals and a popular vector for gene therapy, little is known about the cellular immune responses it evokes in humans. Initial trials using adenovirus vectors have been disappointing, probably owing both to a preexisting immune response to Ad2 and Ad5, the most commonly used vector backbones, and to a response to the transgene. The...

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PMID: 9681413
DOI: 10.1089/hum.1998.9.10-1419

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