Article
Determination of HLA-A*02 antigen status in Hodgkin's disease and analysis of an HLA-A*02-restricted epitope of the Epstein-Barr virus LMP-2 protein.
International journal of cancer - 7 Aug 1997
Bryden H, MacKenzie J, Andrew L, Alexander F E, Angus B, Krajewski A S, Armstrong A A, Gray D, Cartwright R A, Kane E, Wright D H, Taylor P, Jarrett R F
Abstract excerpt
There is good evidence for an association between Epstein-Barr virus (EBV) and Hodgkin's disease (HD). In approximately one-third of cases, the EBV genome is detectable in Reed-Sternberg (RS) cells and there is expression of the viral nuclear antigen EBNA-1 and the latent membrane protein LMP-1....
Topics
- Adolescent
- Adult
- Alleles
- Antigens, Neoplasm
- Antigens, Viral
- HLA-A Antigens
- Herpesviridae Infections
- Herpesvirus 4, Human
- Hodgkin Disease
- Humans
- Immunodominant Epitopes
- Mutation
- Oncogene Proteins, Viral
- Tumor Virus Infections