Article
Mineralocorticoid receptor splice variants in different human tissues.
European journal of endocrinology - 1 Jun 1998
Wickert L, Watzka M, Bolkenius U, Bidlingmaier F, Ludwig M
Abstract excerpt
The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effects or may act...
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