Article
Is N2O-dependent damage 'fixed' by action of the recA locus?
International journal of radiation biology - 1 Jan 1991
Ewing D, Guilfoil D S
Abstract excerpt
Nitrous oxide (N2O) is often a radiation sensitizer of procaryotic cells, although it has little or no effect in recA- strains of E. coli and Saccharomyces. Here we test the hypothesis that N2O-dependent damage is in itself not lethal, but that lethality occurs when this damage is incorrectly repaired by the recA+ strains. Because sensitization by N2O requires the radiolytic production of H2O2, the hypothesis can...
Topics
- DNA Damage
- DNA Repair
- DNA, Bacterial
- Escherichia coli
- Mutation
- Nitrous Oxide
- Radiation-Sensitizing Agents