Stimulation of neuropeptide Y gene expression by brain-derived neurotrophic factor requires both the phospholipase Cgamma and Shc binding sites on its receptor, TrkB.

doi:10.1042/bj3330505

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Article

Stimulation of neuropeptide Y gene expression by brain-derived neurotrophic factor requires both the phospholipase Cgamma and Shc binding sites on its receptor, TrkB.

The Biochemical journal - 1 Aug 1998

Williams A G, Hargreaves A C, Gunn-Moore F J, Tavaré J M

Abstract excerpt

In PC12 cells, it has been previously reported that nerve growth factor stimulates neuropeptide Y (NPY) gene expression. In the current study we examined the signalling pathways involved in this effect by transiently expressing in PC12 cells the receptor (TrkB) for the related neurotrophin, brain...

Topics

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
Brain-Derived Neurotrophic Factor
Calcium
Calcium-Calmodulin-Dependent Protein Kinases
Enzyme Activation
Gene Expression
Isoenzymes
Mutation
Nerve Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropeptide Y

PC12 Cells

Phospholipase C gamma

Phosphorylation

Promoter Regions, Genetic

Protein Kinase C

Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9677306
DOI: 10.1042/bj3330505
PMCID: PMC1219610

Genes

BDNF
NPY

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9677306-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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