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Article

Tumor Suppressors and Cell-Cycle Proteins in Lung Cancer

5 Oct 2011

Abstract excerpt

The cell cycle is the cascade of events that allows a growing cell to duplicate all its components and split into two daughter cells. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, p19, and p18) and...

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PMID: 22007345
DOI: 10.4061/2011/605042

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