Article
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.
Molecular psychiatry - 1 May 1998
Bowen T, Guy C A, Craddock N, Cardno A G, Williams N M, Spurlock G, Murphy K C, Jones L A, Gray M, Sanders R D, McCarthy G, Chandy K G, Fantino E, Kalman K, Gutman G A, Gargus J J, Williams J, McGuffin P, Owen M J, O'Donovan M C
Abstract excerpt
A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia. Despite its modest statistical significance, the study is intriguing for two reasons. First, hKCa3 contains a polymorphic CAG repeat in its coding sequence, with large repeats more common in schizophrenics compared with controls. This is interesting in view of several...
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