Article
Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia.
Biochemical and biophysical research communications - 20 Oct 1998
Li T, Hu X, Chandy K G, Fantino E, Kalman K, Gutman G, Gargus J J, Freeman B, Murray R M, Dawson E, Liu X, Bruinvels A T, Sham P C, Collier D A
Abstract excerpt
hKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been reported, we performed haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium (TDT) in 97 family trios with schizophrenia from SW China. We...
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