Article
Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia.
Biochemical and biophysical research communications - 20 Oct 1998
Li T, Hu X, Chandy K G, Fantino E, Kalman K, Gutman G, Gargus J J, Freeman B, Murray R M, Dawson E, Liu X, Bruinvels A T, Sham P C, Collier D A
Abstract excerpt
hKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been reported, we performed haplotype-based haplotyp...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- China
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Female
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Molecular Sequence Data