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Article

A piece in the puzzle: an ion channel candidate gene for schizophrenia.

Molecular medicine today - 1 Dec 1998

Gargus J J, Fantino E, Gutman G A

Abstract excerpt

Mutations in ion channels have been found to cause a variety of mendelian genetic diseases, and polyglutamine repeat expansion is a newly recognized pathogenic mechanism that causes several rare, genetic, late-onset neurological syndromes. Polymorphic polyglutamine tracts are present in a recently described human, calcium-activated potassium channel, KCNN3 (also known as hKCa3), and alleles of this gene that...

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Source

Identifiers

PMID: 9866821
DOI: 10.1016/s1357-4310(98)01358-6

Genes

KCNN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A piece in the puzzle: an ion channel candidate gene for schizophrenia.PMID 9866821Read ↗

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No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population.Semantic proximity Read ↗

Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?Semantic proximity Read ↗

A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia.Semantic proximity Read ↗

Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population.Semantic proximity Read ↗

A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.Semantic proximity Read ↗

Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.Semantic proximity Read ↗

Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.Semantic proximity Read ↗

Major channels involved in neuropsychiatric disorders and therapeutic perspectivesSemantic proximity Read ↗

Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population.Semantic proximity Read ↗

Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.Semantic proximity Read ↗

Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia.Semantic proximity Read ↗

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