Article
Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease.
Neuroscience letters - 12 Jun 1998
Pirttilä T, Koivisto K, Mehta P D, Reinikainen K, Kim K S, Kilkku O, Heinonen E, Soininen H, Riekkinen P, Wisniewski H M
Abstract excerpt
Levels of soluble amyloid beta protein (sAbeta), amyloid beta precursor protein (APP) and apolipoprotein E (apoE) were examined in cerebrospinal fluid (CSF) obtained twice, at baseline and after 3-year follow-up, from 25 patients with probable Alzheimer's disease (AD). Levels of sAbeta and apoE from patients with the apoE4 allele decreased with time, whereas the levels were similar in patients without apoE4...
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