Article
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Veigl M L, Kasturi L, Olechnowicz J, Ma A H, Lutterbaugh J D, Periyasamy S, Li G M, Drummond J, Modrich P L, Sedwick W D, Markowitz S D
Abstract excerpt
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA microsatellite sequences (MSI). Germ-line hMLH1 mutations are causally associated with inherited MSI colon cancer, and somatic mutations are causally associated with sporadic MSI colon cancer. Previously however, we...
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