Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.

The Journal of infectious diseases - 1 May 1998

Curtis J, Duraisingh M T, Warhurst D C

Abstract excerpt

Plasmodium falciparum present in blood samples collected before and 3 weeks after treatment with either pyrimethamine-sulfadoxine or chlorproguanil-dapsone was analyzed for variants of the genes coding for the target enzymes of antifolate drugs, dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS). Fragments of the genes were amplified by polymerase chain reactions, and variants were identified by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Arginine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genotype

Share to Plasmodium falciparum

Share to Point Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9593041
DOI: 10.1086/517831

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.PMID 9593041Read ↗

Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria.Semantic proximity Read ↗

Antifolates can have a role in the treatment of Plasmodium vivax.Semantic proximity Read ↗

Molecular monitoring of dihydrofolatereductase (dhfr) and dihydropteroatesynthetase (dhps) associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates of Palawan, Philippines.Semantic proximity Read ↗

Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase.Semantic proximity Read ↗

Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil.Semantic proximity Read ↗

Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi.Semantic proximity Read ↗

Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.Semantic proximity Read ↗

Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole.Semantic proximity Read ↗

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.Semantic proximity Read ↗

Point Mutations in the Dihydrofolate Reductase and Dihydropteroate Synthetase Genes and in Vitro Susceptibility to Pyrimethamine and Cycloguanil of Plasmodium falciparum Isolates from Papua New GuineaSemantic proximity Read ↗

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.Semantic proximity Read ↗

Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.