Article
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
The Journal of infectious diseases - 1 May 1998
Curtis J, Duraisingh M T, Warhurst D C
Abstract excerpt
Plasmodium falciparum present in blood samples collected before and 3 weeks after treatment with either pyrimethamine-sulfadoxine or chlorproguanil-dapsone was analyzed for variants of the genes coding for the target enzymes of antifolate drugs, dihydrofolate reductase (DHFR) and dihydropteroate...
Topics
- Amino Acid Sequence
- Animals
- Antimalarials
- Arginine
- Asparagine
- Child
- Dapsone
- Dihydropteroate Synthase
- Drug Therapy, Combination
- Genes, Protozoan
- Genetic Variation
- Genotype
- Humans
- Isoleucine
- Malaria, Falciparum
- Plasmodium falciparum
- Point Mutation
- Polymerase Chain Reaction