Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient trans-splicing of mutated spliced leader exons in Leishmania tarentolae.

The Journal of biological chemistry - 24 Jul 1998

Sturm N R, Fleischmann J, Campbell D A

Abstract excerpt

Every kinetoplastid mRNA receives a common, conserved leader sequence via the process of trans-splicing. In Leishmania tarentolae the precursor spliced leader RNA is 96 nucleotides, with a 39-nucleotide exon that is 7meG-capped and methylated on the first 4 nucleotides. trans-Splicing was inferred from the presence of tagged leader in the high molecular weight RNA population and confirmed for accuracy by cDNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Exons
Share to Introns

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Phenotype

Share to RNA, Messenger

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 9668037
DOI: 10.1074/jbc.273.30.18689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient trans-splicing of mutated spliced leader exons in Leishmania tarentolae.PMID 9668037Read ↗

The Leishmania tarentolae spliced leader contains determinants for association with polysomes.Semantic proximity Read ↗

Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in TrypanosomatidsSemantic proximity Read ↗

In vitro transcription of mutated Leishmania tarentolae spliced leader RNA genes approximates in vivo patterns.Semantic proximity Read ↗

Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryoteSemantic proximity Read ↗

Transcription termination and 3'-End processing of the spliced leader RNA in kinetoplastids.Semantic proximity Read ↗

<i>Trans</i> -Splicing in Trypanosomes: Machinery and Its Impact on the Parasite TranscriptomeSemantic proximity Read ↗

In vivo import of unspliced tRNATyr containing synthetic introns of variable length into mitochondria of Leishmania tarentolae.Semantic proximity Read ↗

Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma bruceiSemantic proximity Read ↗

RNA editing in trypanosomatid mitochondria.Semantic proximity Read ↗

Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilizationSemantic proximity Read ↗

Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity.Semantic proximity Read ↗

Establishment of an in vitro trans-splicing system in Trypanosoma brucei that requires endogenous spliced leader RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.