Expressing mRNAs for presenilin-1 and amyloid precursor protein (APP-695) from same neuronal populations in rat hippocampus.

doi:10.1016/s0361-9230(97)00455-3

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Article

Expressing mRNAs for presenilin-1 and amyloid precursor protein (APP-695) from same neuronal populations in rat hippocampus.

Brain research bulletin - 1 Jun 1998

Shen Y, Li R

Abstract excerpt

Presenilin-1 gene (PS1, s182) encoding a protein that contains seven transmembrane domains was recently identified as a risk factor for Alzheimer's disease (AD). Mutations on this gene may contribute to pathogenesis of AD. In this study, we used in situ hybridization histochemistry to detect the...

Topics

Amyloid beta-Protein Precursor
Animals
Cerebral Cortex
Hippocampus
In Situ Hybridization
Male
Membrane Proteins
Mice
Mice, Transgenic
Mutation
Neurons
Presenilin-1
RNA, Messenger
Rats
Rats, Sprague-Dawley
Tissue Distribution

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