Volatile anesthetic additivity and specificity in Saccharomyces cerevisiae: implications for yeast as a model system to study mechanisms of anestheitc action.

Abstract excerpt

BACKGROUND: In animals, combinations of volatile anesthetics are additive for inducing anesthesia. Furthermore, although there is a correlation between lipophilicity and anesthetic potency, not all volatile lipophilic compounds are anesthetic. Previously the authors demonstrated the effects of volatile anesthetics on the eukaryote Saccharomyces cerevisiae (yeast). To further relate anesthetic action in this...

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