Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast.

Molecular and cellular biology - 1 Dec 1999

Wolfe D, Reiner T, Keeley J L, Pizzini M, Keil R L

Abstract excerpt

To investigate the mechanism of action of volatile anesthetics, we are studying mutants of the yeast Saccharomyces cerevisiae that have altered sensitivity to isoflurane, a widely used clinical anesthetic. Several lines of evidence from these studies implicate a role for ubiquitin metabolism in cellular response to volatile anesthetics: (i) mutations in the ZZZ1 gene render cells resistant to isoflurane, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics, Inhalation
Share to Cysteine Endopeptidases
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Halothane

Share to Isoflurane

Share to Ligases

Share to Ubiquitin-Protein Ligase Complexes

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 10567550
DOI: 10.1128/MCB.19.12.8254
PMCID: PMC84909

Genes

MDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast.PMID 10567550Read ↗

RRD1, a component of the TORC1 signalling pathway, affects anaesthetic response in Saccharomyces cerevisiae.Semantic proximity Read ↗

Volatile anesthetic additivity and specificity in Saccharomyces cerevisiae: implications for yeast as a model system to study mechanisms of anestheitc action.Semantic proximity Read ↗

Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.Semantic proximity Read ↗

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae).Semantic proximity Read ↗

Links between mutations in functionally separate arms of mitochondrial complex I and responses to volatile anesthetics.Semantic proximity Read ↗

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Determination of Ubiquitin Fitness Landscapes Under Different Chemical Stresses in a Classroom SettingSemantic proximity Read ↗

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.