Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox.

doi:10.1016/s0166-6851(98)00037-1

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Article

Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox.

Molecular and biochemical parasitology - 1 Jun 1998

Murta S M, Gazzinelli R T, Brener Z, Romanha A J

Abstract excerpt

Twenty-seven Trypanosoma cruzi strains, susceptible or naturally resistant to the nitroderivatives benznidazole and nifurtimox, were analyzed using the following molecular markers: (i) isoenzyme patterns of six enzymes; (ii) genetic variability assayed by randomly amplified polymorphic DNA (RAPD)...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Brazil
Chagas Disease
DNA, Protozoan
DNA, Ribosomal
Drug Resistance
Exons
Genes, Protozoan
Genetic Variation
Glucose-6-Phosphate Isomerase
Humans
Hypoxanthine Phosphoribosyltransferase
Isoenzymes
Nifurtimox
Nitroimidazoles
Polymorphism, Genetic
Random Amplified Polymorphic DNA Technique

Source

Open in PubMed

Identifiers

PMID: 9662705
DOI: 10.1016/s0166-6851(98)00037-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9662705-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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