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Article

Genetic Characterization of Trypanosoma cruzi I Populations from an Oral Chagas Disease Outbreak in Venezuela: Natural Resistance to Nitroheterocyclic Drugs.

ACS infectious diseases - 10 Mar 2023

Muñoz-Calderón Arturo, Ramírez José Luis, Díaz-Bello Zoraida, Alarcón de Noya Belkisyolé, Noya Oscar, Schijman Alejandro G

Abstract excerpt

The oral transmission of Chagas disease (oCD) in Venezuela announced its appearance in 2007. Different from other populations affected by oCD and despite close supervision during treatment with nitroheterocyclic drugs, the result was treatment failure. We studied genetic features of natural bloodstream parasite populations and populations after treatment of nine patients of this outbreak. In total, we studied six...

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PMID: 36780430
DOI: 10.1021/acsinfecdis.2c00569

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