Article
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.
Oncogene - 11 Jun 1998
Chevillard S, Radicella J P, Levalois C, Lebeau J, Poupon M F, Oudard S, Dutrillaux B, Boiteux S
Abstract excerpt
The human OGG1 gene encodes a DNA glycosylase activity catalysing the excision of the mutagenic lesion 7,8-dihydro-8-oxoguanine from oxidatively damaged DNA. The OGG1 gene was localized to chromosome 3p25, a region showing frequent loss of heterozygosity (LOH) in lung and kidney tumours. In this...
Topics
- Carcinoma, Small Cell
- DNA Damage
- DNA Repair
- DNA-Formamidopyrimidine Glycosylase
- Endodeoxyribonucleases
- Humans
- Kidney Neoplasms
- Lung Neoplasms
- Mutation
- N-Glycosyl Hydrolases
- Oxidation-Reduction