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Article

Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.

Oncogene - 11 Jun 1998

Chevillard S, Radicella J P, Levalois C, Lebeau J, Poupon M F, Oudard S, Dutrillaux B, Boiteux S

Abstract excerpt

The human OGG1 gene encodes a DNA glycosylase activity catalysing the excision of the mutagenic lesion 7,8-dihydro-8-oxoguanine from oxidatively damaged DNA. The OGG1 gene was localized to chromosome 3p25, a region showing frequent loss of heterozygosity (LOH) in lung and kidney tumours. In this study, we have analysed by RT-PCR the expression of OGG1 in 25 small cell lung cancers, in 15 kidney carcinomas and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9662341
DOI: 10.1038/sj.onc.1202096

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.PMID 9662341Read ↗

hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population.Semantic proximity Read ↗

Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney.Semantic proximity Read ↗

Novel mutations of OGG1 base excision repair pathway gene in laryngeal cancer patients.Semantic proximity Read ↗

Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer.Semantic proximity Read ↗

The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer.Semantic proximity Read ↗

Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.Semantic proximity Read ↗

DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention.Semantic proximity Read ↗

The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk.Semantic proximity Read ↗

OGG1 gene sequence variation in head and neck cancer patients in Pakistan.Semantic proximity Read ↗

DNA Base-Excision Repair Genes OGG1 and NTH1 in Brazilian Lung Cancer Patients.Semantic proximity Read ↗

Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer.Semantic proximity Read ↗

OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.Semantic proximity Read ↗

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