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Article

Rare mutations in a domain crucial for V3-loop structure prevail in replicating HIV from long-term non-progressors.

AIDS (London, England) - 18 Jun 1998

Menzo S, Sampaolesi R, Vicenzi E, Santagostino E, Liuzzi G, Chirianni A, Piazza M, Cohen O J, Bagnarelli P, Clementi M

Abstract excerpt

OBJECTIVE: To evaluate the role of the selective forces exerted by the host on the HIV-1 structures involved in viral entry. DESIGN AND METHODS: The V3 region of the env gene was analysed in cell-free HIV-1 RNA from 17 infected subjects: 11 long-term non-progressors (LTNP) and six symptomless, typical progressor patients. To evaluate the potential biological significance of one of the rare variants detected in...

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PMID: 9662194

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