Article
Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells.
Cancer research - 1 Jul 1998
Frade R, Rodrigues-Lima F, Huang S, Xie K, Guillaume N, Bar-Eli M
Abstract excerpt
We previously demonstrated that highly metastatic human melanoma cells secrete a 41 kDa proteinase that cleaves C3, the third component of complement, and shares antigenic determinants with procathepsin-L. Thus, we herein transfected the nonmetastatic DX-3 melanoma cells with the procathepsin-L c...
Topics
- Animals
- Cathepsin L
- Cathepsins
- Complement C3
- Enzyme Precursors
- Humans
- Melanoma
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phenotype
- Skin Neoplasms
- Transfection
- Tumor Cells, Cultured